Canine Cardiomyopathy and Colostrum

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Colostrum and Canine Cardiomyopathy

Dear consumer,

Your inquiry regarding dilated cardiomyopathy in a canine and theassociatedbenefits of colostrum has been forwarded to me. I am a business and technologyconsultant with extensive knowledge and experience regarding the formation of bovinecolostrum and its applications in humans an animals, particularly as it applies to specific medicalconditions.

Cardiomyopathy is a type of heart disease in which the heart is abnormally enlarged, thickenedor stiffened. This usually weakens the heart's ability to pump blood. The condition ordinarilybegins in the lower chambers of the heart (the ventricles) and, in more severe cases, may affectthe walls of the upper chambers of the heart (the atria or auricles).

There are two general types of cardiomyopathies, ischemic (lack of oxygen) and non-ischemic.In an ischemic cardiomyopathy, there is a hardening of the arteries on the surface of the heart,reducing the amount of oxygen-rich blood delivered to the muscle. Eventually, the heart muscleenlarges due to the extra work that it must do in the absence of enough oxygen-rich blood. Thespecific cause of non-ischemic cardiomyopathy is not known, but it is associated with geneticfactors, viral infection, the build-up of fats and proteins in the heart muscle and an excess of iron(hemochromatosis) in the heart. In humans, the excess use of alcohol can also play a role.There are three main types of non-ischemic cardiomyopathies.

Dilated cardiomyopathy which involves dilation or enlargement of the lower-left chamber of theheart (the left ventricle).

Hypertrophic cardiomyopathy which involves an abnormal growth of muscle fibers in the heart muscle.Restrictive cardiomyopathy which involves restriction of the blood flow into the lower chambersof the heart (the ventricles) because their walls are too rigid.

In humans, dilated cardiomyopathy accounts for almost 87% of all non-ischemiccardiomyopathies. In dogs, this condition is also the most common form of the condition andusually starts at between 4-10 years of age, occurring most frequently in larger breeds.The following is a documented personal experience of an individual with congestive heart failurefollowing a diagnosis of cardiomyopathy. As the summary relates, the individual routinelysupplemented his diet with a high quality first milking colostrum.

"At the time he was diagnosed with congestive heart failure, Arlan Reynolds had already hadother heart problems but he had somehow been able to maintain his work and his outsideinterests. However, congestive heart failure meant limiting physical exertion for the rest of hislife. "I was told that I had an enlarged heart - that there was a certain percentage of it that wasactually 'dead.' I was given very little hope of ever having a normal life again," recalls Arlan.When he discovered colostrum and began taking it, Arlan had no expectation for what mighthappen. He faithfully took 8-10 capsules/day and he continued with his regular nutritionalprogram. As time went on, he noticed an increase in energy and stamina but he had no idea whatwas really happening until 12 months later when he went in for his annual physical exam. "Mydoctor took X-rays of my heart along with other routine tests," says Arlan. "He compared the Xrayswith the ones which had originally been taken. Then he sent me to a special facility to havehis findings substantiated. After numerous other tests, including more X-rays, an EKG and anecho-cardiogram, the doctor told me that he didn't understand what had taken place, but that allthe tests indicated my heart had returned to normal size," relates Arlan. My doctor said that in allhis years of practice, he had never seen an enlarged heart return to normal size. Arlan's nextquestion to the doctor was, "Are you telling me that now I can play racquetball?" The doctors'sreply, was simply, "I would highly recommend it."

Excerpted from an article in The Colostrum Option vol 3, 2000, titled, "Doctors Can't ExplainHis Recovery From Congestive Heart Failure."

The benefits realized here were most likely due to the small amounts of growth hormone andsubstantial amounts of insulin-like growth factor-1 present in high quality bovine colostrum.Growth hormone is extremely potent and, thus, only a small quantity is required. It directlyinfluences the generation of new cells and the repair of existing tissues.

By contrast, insulin-like growth factor-1 is far more powerful and has a much broader range ofeffects on cell development, the control of metabolism and the derivation of energy.

Insulin-like growth factor-1 (IGF-1), and its closely related counterpart insulin-like growthfactor-2 (IGF-2), are potent hormones that are found in association with almost all cells in thebody. IGF-1 is the best described and most potent of this pair. These molecules are produced byall mammals and, in every case, have a very similar chemical structure regardless of the species.IGF-1 is essential for normal cell growth and tissue repair.

Scientific knowledge about the IGFs, what they do and how they act on cells in the body hasevolved very rapidly during the past few years. It is now known that there are specific receptorson almost all cells in the body capable of interacting with IGF-1 and triggering a series ofchemical events within the cell. There are also 6 different proteins present inside the cell and oncell surfaces that control the actions of IGF-1 on the cell after it binds to a receptor. These arecalled insulin-like growth factor binding proteins (IGFBPs). In addition, there are at least 87other related proteins either capable of binding to IGF-1, altering its actions, or influencing theeffects of the IGFBPs. These are called insulin-like growth factor binding protein-relatedproteins (IGFBP-rPs). The entire collection of these proteins is referred to as the insulin-likegrowth factor binding protein (IGFBP) superfamily. The key event that triggers the effects of anyof these proteins appears to be the interaction of IGF-1 with its specific cell-surface receptor, anevent that some of these proteins regulate.

The multitude of available IGF-1binding proteins and related proteins available in the cell isindicative of the many potential effects that the binding of IGF-1 to its specific cell-surfacereceptor can have on cells. To keep these many effects under control, some of the bindingproteins act as checks and balances, allowing the secondary chemical switches in a cell to beturned on and then turning them off when it is appropriate. Therefore, IGF-1 is like the captainof a ship. When it binds to its specific receptor, the ship can move forward, but there are allkinds of systems in place to keep it moving at the right speed and in the right direction. The maintriggered events include activation of the process by which the cell grows and reproduces itselfand maintenance of the metabolic pathways by which the cell converts glucose into glycogenand uses amino acids to create proteins. The actual pathway by which the cell uses glucose andconverts it to glycogen is first switched on by the binding of insulin to its specific cell surfacereceptors. Glycogen is stored in the liver and muscles and is the main source of readily availableenergy when the muscles are exercised. The IGFBP superfamily also has a direct role in how thecell uses amino acids to build proteins. As we age, the ability of our body to create an adequatesupply of IGF-1 is diminished. Thus, by eating a well-balanced diet and maintaining a constantsupply of IGF-1 in our body, we can keep the ship moving at the right speed and in the rightdirection. And when we exercise this becomes even more critical since there is an increaseddemand for glycogen to provide energy to our muscles and the preference is to build moremuscle protein. Even more importantly, as we age the cells in our body do not reproducethemselves as well and, since IGF-1 is a primary factor in the ability of cells to grow andreproduce, it is highly desirable to have an appropriate level of IGF-1 in the circulation throughdietary supplementation to limit the ever increasing rate of cell death.

References:

Anwar A, Gaspz JM, et al; Effect of congestive heart failure on the insulin-like growth factor-1 system, Am JCardiol 2002; 90(12): 1402-5.Hwa V, Oh Y, Rosenfeld RG; The insulin-like growth factor binding protein (IGFBP) superfamily, Endocr Rev1999; 20(6): 761-87.LeRoith D; Insulin-like growth factor receptors and binding proteins, Endocrinol Metab 1996; 10(1): 49-73.Kohn DT, Kopchick JJ; Growth hormone recptor antagonists, Minerva Endocrinol 2002; 27(4): 287-98.Li H, Dimayuga P, et al; Arterial injury in mice with severe insulin-like growth factor-1 (IGF-1) deficiency, JCardiovasc Pharmacol Ther 2002; 7(4): 227-33.Rosenfeld RG, Hwa V, et al; The insulin-like growth factor binding protein superfamily: new perspectives,Pediatrics 1999; 104(4): 1018-21.van den Beld AW, Bots ML, et al; Endogenous hormones and carotid atherosclerosis in elderly men, Am JEpidemiol 2003; 157(1): 25-31.

I hope that this information will be useful and will help you to understand something more aboutyour dog's condition and some of the benefits that can be realized by routine use of a high qualitybovine colostrum product from Immune-Tree.

To your good health - always.

Sincerely,

Alfred E. Fox, Ph.D.

Dr. Alfred E. Fox holds a Ph.D. from Rutgers University in Microbiology (Immunochemistry)and has more than 25 years of senior management experience at Carter-Wallace, Baxter DadeDivision and Warner-Lambert, where he was responsible for research and development andregulatory affairs. He was also the founder and president of two biotechnology companiesfocused on agribusiness and environmental monitoring, respectively. For the past 15 years, Dr.Fox has been the President of Fox Associates, a business and technology consulting firm servingsmall- to mid-size companies in the human and animal healthcare fields. He focuses primarilyon marketing and regulatory issues and for the past 10 years has continuously consulted tobovine colostrum manufacturers, where he has gained regulatory approval for their products,been a technical advisor, helped design and develop marketing strategies and served as anexpert witness in legal matters.

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